Permanent - Quality Lead - Pharmaceutical Manufacturing - Ekurhuleni (East Rand) - South Africa

Job Number: 79192


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79192
Permanent
Quality Lead - Pharmaceutical Manufacturing
GMP,Embed ALCOA,CAPA,RCA
Manufacture
Ekurhuleni (East Rand)
Gauteng

Quality Lead - Pharmaceutical Manufacturing (Lean, High-speed operation)

Reports to: General Manager

Purpose of Role:

To act as the accountable Quality authority for a lean pharmaceutical manufacturing site operating high-speed, continuous production lines at >90% efficiency. The Quality Lead must provide full ownership of the Quality Management System while remaining operationally hands on in a fast-paced, resource-constrained environment. This role requires a pragmatic pharmaceutical Quality Leader who understands how to embed GMP controls without slowing production, and who can balance compliance with operational excellence. The Quality Lead will serve as the primary customer-facing Quality representative and must be capable of independently assessing risk, leading audits, and driving pharmaceutical discipline within a micro-site. This is not a corporate QA role. This is a hands-on site Quality Owner role.

Key Responsibilities:

Quality System Ownership (Lean, High-Speed Environment) 

Own and continuously improve the site QMS (GMP, SOPs, records, forms, templates) 

Embed ALCOA+ data integrity principles into daily operations without disrupting line efficiency 

Lead internal audits, management review, and quality governance 

Personally verify GMP-critical records and processes on the production floor

Build simple, effective quality systems suited to high-speed continuous manufacturing

Regulatory & Customer Interface:

Act as primary Quality contact for customers and regulators 

Lead customer audits and inspections end-to-end 

Own RCA development and CAPA effectiveness (systemic, risk-based, operationally realistic)

Ensure commitments protect product integrity while supporting production continuity

Risk Management & Compliance:

Hands-on ownership of: 

Validation lifecycle (process, cleaning, utilities) 

Contamination control strategy 

IPC programs aligned to continuous production 

Water system oversight

Stability programs 

Data integrity governance 

Change control and deviations Proactively identify risks before customer escalation while maintaining operational flow.

Manufacturing Quality Oversight (Critical):

Daily floor presence across: Dispensing, Packaging, Laboratory, Production

Direct involvement in problem-solving on running lines •

Ensure GMP-critical equipment maintenance is documented and controlled without unnecessary downtime 

Oversee batch release readiness 

Challenge legacy practices that do not meet pharmaceutical expectations or lean efficiency targets

Leadership in a Micro, High-Performance Operation:

Lead a small Quality team (QA/QC/Admin)

Coach operators and supervisors on GMP behaviour in a fast-moving environment 

Set clear expectations and accountability

Be comfortable operating without layers of support

Balance regulatory compliance with >90% production efficiency targets

Lead cultural reset within the Quality function, improving engagement, retention, and accountability while restoring momentum in a high-pressure, lean operation. This role requires someone who can protect quality while lines are running, not after the fact.


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Mandatory Requirements Experience

Education:

BSc / BPharm / BTech or equivalent in Life Sciences, Chemistry, Pharmacy, or related field

Formal GMP training essential

Experience:

Minimum 8–10 years pharmaceutical manufacturing Quality experience

At least 3–5 years in site Quality leadership

Proven experience in:

Lean or small pharmaceutical manufacturing environments

High-speed continuous production operations

Sites operating at >85–90% efficiency targets

Demonstrated ownership of:

GMP systems

ALCOA+ data integrity

Validation lifecycle

CAPA management

Customer and/or regulatory audits Cosmetics-only, food-only, or ISO-only backgrounds are not acceptable.

Large corporate QA profiles without hands-on site ownership experience are not suitable.

Technical Competence Strong practical knowledge of: 

GMP compliance 

Process & cleaning validation

Contamination control

Risk assessments

Deviations & CAPA 

Water systems 

IPC in continuous manufacturing 

Stability programs

Preventive maintenance frameworks Behavioural Profile (Non-Negotiable)

Must demonstrate: 

Hands-on leadership 

Independent judgement 

Comfort challenging operations and engineering

Ownership mindset (“my system, my risk”) 

Customer-facing confidence 

Ability to lead under audit pressure

Zero tolerance for undocumented practices

Ability to operate at speed without compromising compliance Builder mentality — not caretaker. 

What Success Looks Like:

Quality risks identified internally before customer escalation 

Audits anticipated, not reacted to 

Validation and contamination control embedded into daily production 

CAPAs systemic and operationally realistic 

Quality visible daily on the floor

Lean site running at >90% efficiency with pharmaceutical discipline

BSc / BPharm / BTech or equivalent in Life Sciences, Chemistry, Pharmacy
Bachelors
Available

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